“Driving Test: ‘Gene drive’ techniques have the potential to alter whole populations. Regulators
A gene drive is a new technique that is able to alter entire populations. It will be able to achieve the removal of malaria-carrying mosquitos and threats by invasive species. This technique has been made possible by the new, affordable CRISPR technology that allows precise genetic engineering. Researchers and regulators should be sure to be thorough before allowing this method of genetic engineering to be used.
Esvelt, Kevin M., Andrea L. Smidler, Flaminia Catteruccia, and George M. Church. “Concerning
RNA-guided gene drives for the alteration of wild populations.” eLife. 17 Jul. 2014. Print. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117217/
Esvelt, Kevin M., Andrea L. Smidler, Flaminia Catteruccia, and George M. Church. “Concerning
RNA-guided gene drives for the alteration of wild populations.” eLife. 17 Jul. 2014. Print. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117217/
This is a very thorough source that describes the evolutionary stability that will be affected in the event of an unnatural gene drive. It discusses limitations, safeguards, reversibility and many other topics that will need to be considered before a gene drive should be advised. It argues that it is very important to explore every factor before pursuing the use of a gene drive. Biological systems are so hard to predict that it is extremely difficult to understand the possible repercussions that could come with this sort of tampering with the environment.
Ledford, Heidi. “CRISPR, the disruptor.” Nature 522.7554. 3 Jul. 2015. Print. http://www.nature.com/news/crispr-the-disruptor-1.17673
This article describes the new, amazing gene drive technology, CRISPR. It is affordable, quick, and easy to use unlike many of the past methods of genetic engineering. The author says that there is a lot that still has to be done before CRISPR can be safely used. With this new technology it will be possible to edit disease of out a genome.
Oye, Kenneth A., et al. “Regulating Gene Drives.” Science 345.6197 (8 Aug. 2014): 626-628.
Print. http://www.sciencemag.org/content/345/6197/626.full
This source presents the limitations of gene drives as well as some of the risks. Because gene drives are carried out through sexual reproduction, they will not be effective in altering bacterial and viral populations. A gene drive also takes multiple generations to be carried out and that can mean waiting a long time for species with long life expectancies and long developmental periods. This source also discusses some of the issues relating to regulatory problems with gene drives. Because it is such a new and booming technology, CRISPR has not yet been properly regulated.
Webber, Bruce L, Raghu, S., and Edwards, Owain R. “Opinion: Is CRISPR-based gene drive a
biocontrol silver bullet or global conservation threat?” PNAS 112.34. N.d. Print. http://www.pnas.org/content/112/34/10565.full
This article explores what could possibly happen as a result of gene drives. It is sure to describe the precision and incredible ability of the CRISPR technique of genetic engineering, but it also lists many risks for this new technology. PNAS references events from the past and non-target issues can also be impacted. It warns that causing the extinction of species is dangerous and that combatting invasive species could not be worth the other ecological consequences.
This article describes the new, amazing gene drive technology, CRISPR. It is affordable, quick, and easy to use unlike many of the past methods of genetic engineering. The author says that there is a lot that still has to be done before CRISPR can be safely used. With this new technology it will be possible to edit disease of out a genome.
Oye, Kenneth A., et al. “Regulating Gene Drives.” Science 345.6197 (8 Aug. 2014): 626-628.
Print. http://www.sciencemag.org/content/345/6197/626.full
This source presents the limitations of gene drives as well as some of the risks. Because gene drives are carried out through sexual reproduction, they will not be effective in altering bacterial and viral populations. A gene drive also takes multiple generations to be carried out and that can mean waiting a long time for species with long life expectancies and long developmental periods. This source also discusses some of the issues relating to regulatory problems with gene drives. Because it is such a new and booming technology, CRISPR has not yet been properly regulated.
Webber, Bruce L, Raghu, S., and Edwards, Owain R. “Opinion: Is CRISPR-based gene drive a
biocontrol silver bullet or global conservation threat?” PNAS 112.34. N.d. Print. http://www.pnas.org/content/112/34/10565.full
This article explores what could possibly happen as a result of gene drives. It is sure to describe the precision and incredible ability of the CRISPR technique of genetic engineering, but it also lists many risks for this new technology. PNAS references events from the past and non-target issues can also be impacted. It warns that causing the extinction of species is dangerous and that combatting invasive species could not be worth the other ecological consequences.
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